​1)    Ohta, M. Koshida, S. Jimbo, I. Oda, M. Inoue, R. Tsukahara, T. Terahara, M. Nakamura, Y. Maruo, Y. Highest concentration of breast milk-derived exosomes in colostrum. Pediatrics International, 2022. https://doi.org/10.1111/ped.15346
2)    Shigeno, Y. Liu, H. Sano, C. Inoue, R. Niimi, K. Nagaoka, K. Individual variations and effects of birth facilities on the fecal microbiome of laboratory-bred marmosets (Callithrix jacchus) assessed by a longitudinal study. PLOS ONE, 2022 https://doi.org/10.1371/journal.pone.0273702.
3)    Miura, H. Jimbo, I. Oda, M. Noguchi, M. Kawasaki, K. Osada-Oka, M. Tsukahara, T. Inoue, R. Effect of Porcine Colostral Exosomes on T Cells in the Peripheral Blood of Suckling Piglets. Animals, 2022. 12(17), 2172. https://doi.org/10.3390/ani12172172 Corresponding author
4)    Harayama, T. Tsukahara, T. Fukuta, K. Oda, M. Inoue, R. Immunocyte Populations Observed from Birth to Weaning in Blood, Spleen and Mesenteric Lymph Nodes of Piglets. Animals 2022, 12(11), 1445; https://doi.org/10.3390/ani12111445.
5)    Imai, T. Inoue, R. Nishida, A. Yokota, Y. Morishima, S. Kawahara, M. Kusada, H. Tamaki, H. Andoh, A. Features of the gut prokaryotic virome of Japanese patients with Crohn’s disease. Journal of Gastroenterology, 2022, 57, 559-570.
6)    Yasuda, R. Kamada, K. Murakami, T. Inoue, R. Mizushima, K. Hirose, R. Inoue, K. Dohi, O. Yoshida, N. Katada, K. Uchiyama, K. Handa, O. Ishikawa, T. Takagi, T. Konishi, H. Naito, Y. Itoh, Y. Astaxanthin attenuated the stress-induced intestinal motility disorder via altering the gut microbiota. International Journal for Vitamin and Nutrition Research. 2022, https://doi.org/10.1024/0300-9831/a000756.
7)    Kitae, H. Takagi, T. Naito, Y. Inoue, R. Azuma, Y. Torii, T. Mizushima, K. Doi, T. Inoue, K. Dohi, O. Yoshida, N. Kamada, K. Uchiyama, K. Ishikawa, T. Konishi, H. Itoh, Y. Gut Microbiota Associated with Clinical Relapse in Patients with Quiescent Ulcerative Colitis. Microorganisms. 2022 May 18;10(5):1044. doi: 10.3390/microorganisms10051044.
8)    Takagi, T. Inoue, R. Oshima, A. Sakazume, H. Ogawa, K. Tominaga, T. Mihara, Y. Sugaya, T. Mizushima, K. Uchiyama, K. Itoh, Y. Naito, Y. Typing of the Gut Microbiota Community in Japanese Subjects. Microorganisms. 2022 Mar 20;10(3):664. doi: 10.3390/microorganisms10030664.
9)    Sakakida, T. Ishikawa, T. Doi, T. Morita, R. Endo, Y. Matsumura, S. Ota, T. Yoshida, J. Hirai, Y. Mizushima, K. Higashimura, Y. Inoue, K. Okayama, T. Uchiyama, K. Takagi, T. Abe, A. Inoue, R. Itoh, Y. Naito, Y. Water-soluble dietary fiber alleviates cancer-induced muscle wasting through changes in gut microenvironment in mice. Cancer Sci. 2022 May;113(5):1789-1800. doi: 10.1111/cas.15306.
10)    Martini, V. Edmans, M. Gubbins, S. Jayaraman, S. Paudyal, B. Morgan, S. McNee, A. Morin, T. Rijal, P. Gerner, W. Sewell, A. K. Inoue, R. Bailey, M. Connelley, T. Charleston, B. Townsend, A. Beverley, P. Tchilian, E. Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells. Mucosal immunology, 2022, 15(3), 428–442. https://doi.org/10.1038/s41385-021-00478-4
11)    Kono, Y. Inoue, R. Teratani, T. Tojo, M. Kumagai, Y. Morishima, S. Koinuma, K. Lefor, AK. Kitayama, J. Sata, N. Horie, H. The Regional Specificity of Mucosa-Associated Microbiota in Patients with Distal Colorectal Cancer. Digestion. 2022;103(2):141-149. doi: 10.1159/000519487.
12)    Shimada, K. Nohara, M. Yasuoka, A. Kamei, A. Shinozaki, F. Kondo, K. Inoue, R. Kondo, T. Abe, K. Mouse Model of Weak Depression Exhibiting Suppressed cAMP Signaling in the Amygdala, Lower Lipid Catabolism in Liver, and Correlated Gut Microbiota. Frontiers in behavioral neuroscience, 2022, 16, 841450. https://doi.org/10.3389/fnbeh.2022.841450
13)    Inoue, R. Otabi, H. Yamashita, T. Takizawa, N. Kido, T. Sugiyama, A. Ozeki, M. Abe, A. Tsukahara, T. Effects of partially hydrolyzed guar gum supplementation on the fecal microbiotas of piglets. Pathogens, 2021, 1;10(11):1420. doi: 10.3390/pathogens10111420. Corresponding author
14)    Inatomi, T. Tsukahara, T. Romero-Perez, A, G. Inoue, R. Combined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial. Agriculture, 2021, 11(11), 1058; https://doi.org/10.3390/agriculture11111058 
15)    Liyanage, G, G. Inoue, R. Fujitani, M. Ishijima, M. Shibutani, T. Abe, K. Kishida, T. Okada, S. Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats. Nutrients, 2021, 13(11), 3759; https://doi.org/10.3390/nu13113759
16)    Fukushima, S. Shiotani, A. Matsumoto, H. Handa, O. Handa, Y. Osawa, M. Murao, T. Umegaki, E. Kawano, M. Inoue, R. Naito, Y. Comparison of mucosa-associated microbiota in Crohn's disease patients with and without anti-tumor necrosis factor-α therapy. Journal of clinical biochemistry and nutrition, 2022, 70(2), 182–188.
17)    Kondo, Y. Hashimotom, Y. Hamaguchi, M. Ando, S. Kaji, Y. Sakai, R. Inoue, R. Kashiwagi, S. Mizushima, K. Uchiyama, K. Takagi, T. Naito, Y. Fukui, M. Unique Habitual Food Intakes in the Gut Microbiota Cluster Associated with Type 2 Diabetes Mellitus. Nutrients, 2021, 13(11); 3816, https:// doi.org/10.3390/nu13113816.
18)    Morishima, S. Oda, N. Ikeda, H. Segawa, T. Oda, M. Tsukahara, T. Kawase, Y. Takagi, T. Naito, Y. Fujibayashi, M. Inoue, R. Altered Fecal Microbiotas and Organic Acid Concentrations Indicate Possible Gut Dysbiosis in University Rugby Players: An Observational Study. Microorganisms 2021. 9(8), 1687; https://doi.org/10.3390/microorganisms9081687 Corresponding author
19)    Ohta, M. Koshida, S. Jimbo, I. Oda, M. Inoue, R. Tsukahara, T. Terahara, M. Yanagi, T. Nakahara, S. Shibata, M. Tsutsui, H. Yoshida, D. Furukawa, O. Maruo, Y. Chronological changes of serum exosome in preterm infants: A prospective study. Pediatrics International 2021. https://doi.org/10.1111/ped.14933.
20)    Miura, H. Hashimoto, T. Kawanishi, Y. Kawauchi, H. Inoue, R. Shoji, N. Saito, K. Sekiya, M. Saito, Y. Yasuda, J. Yonezaka, C. Endo, T. Kasuya, H. Suzuki, Y. Kobayashi, Y. Koike, S. Identification of the core rumen bacterial taxa and their population dynamics during the fattening period in Japanese Black cattle. Animal Science Journal 2021, in press.
21)    Ogawa, C. Inoue, R. Yonejima, K. Hisa, Y. Yamamoto, T. Suzuki, T. Supplemental Leuconostoc mesenteroides strain NTM048 attenuates imiquimod-induced psoriasis in mice. Journal of Applied Microbiology 2021, https://doi.org/10.1111/jam.15161.
22)    Higashimura, Y. Hirabayashi, M. Nishikawa, H. Inoue, R. Nagai, E. Matsumoto, K. Enomoto, T. Mizushima, K. Takagi, T. Naito, Y. Dietary intake of yacon roots (Smallanthus sonchifolius) affects gut microbiota and fecal mucin and prevents intestinal inflammation in mice. Journal of Clinical Biochemistry and Nutrition, 2021 Nov;69(3):272-279. doi: 10.3164/jcbn.20-203.
23)    Yamashita, T. Tai, S. Tsukahara, T. Inoue, R. Fusobacterium nucleatum impedes remission of colitis in a mouse model. Bioscience Biotechnology and Biochemistry, 2021, in press. Corresponding author
24)    Matsumoto, H. Shiotani, A. Katsumata, R. Fukushima, S. Handa, Y. Osawa, M. Murao, T. Handa, O. Umegaki, E. Inoue, R. Naito, Y. Mucosa-asscociated microbiota in patients with irritable bowel syndrome: a comparison of subtypes. Digestion 2021, 102(1), 49-56.
25)    Sugitani, Y. Inoue, R. Inatomi, O. Nishida, A. Morishima, S. Imai, T. Kawahara, M. Naito, Y. Andoh, A. Mucosa-associated gut microbiome in Japanese patients with functional constipation. Journal of Clinical Biochemistry and Nutrition, 2020, in press.
26)    Morishima, S. Aoi, W. Kawamura, A. Kawase, T. Takagi, T. Naito, Y. Tsukahara, T. Inoue, R. Intensive, prolonged exercise seemingly causes gut dysbiosis in female endurance runners. Journal of clinical biochemistry and nutrition, 2020, in press. Corresponding author
27)    Tsukahara, T. Kimura, Y. Inoue, R. Iwata, T. Preliminary investigation of the use of dietary supplementation with probiotic Bacillus subtilis strain QST713 shows that it attenuates antimicrobial‐induced dysbiosis in weaned piglets. Animal Science Journal, 2020, 91(1), e13475..
28)    Takagi, T. Naito, Y. Kashiwagi, S. Uchiyama, K. Mizushima, K. Kamada, K. Ishikawa, T. Inoue, R. Okuda, K. Tsujimoto, Y. Ohnogi, H. Itoh, Y. Changes in the Gut Microbiota are Associated with Hypertension, Hyperlipidemia, and Type 2 Diabetes Mellitus in Japanese Subjects. Nutrients 2020. 12, 2996.
29)    Uryu, H. Tsukahara, T. Ishikawa, H. Oi, M. Otake, S. Yamane, I. Inoue, R. Comparison of Productivity and Fecal Microbiotas of Sows in Commercial Farms. Microorganisms 2020. 8, 1469. Corresponding author
30)    Komiya, S. Naito, Y. Okada, H. Matsuo, Y. Hirota, K. Takagi, T. Mizushima, K. Inoue, R. Abe, A. Morimoto, Y. Characterizing the gut microbiota in females with infertility and preliminary results of a water-soluble dietary fiber intervention study. Journal of clinical biochemistry and nutrition, 2020. 67(1), 105–111.
31)    Naito, Y. Ushiroda, C. Mizushima, K. Inoue, R. Yasukawa, Z. Abe, A. Takagi, T. 
Epigallocatechin-3-gallate (EGCG) attenuates non-alcoholic fatty liver disease via modulating the interaction between gut microbiota and bile acids. Journal of clinical biochemistry and nutrition, 2020. 67(1), 2–9.
32)    Hashimoto, Y. Hamaguchi, M. Kaji, A. Sakai, R. Osaka, T. Inoue, R. Kashiwagi, S. Mizushima, K. Uchiyama, K. Takagi, T. Naito, Y. Fukui, M.
Intake of sucrose affects gut dysbiosis in patients with type 2 diabetes. 2020. Journal of diabetes investigation, 10.1111/jdi.13293.
33)    Kambe, J. Sasaki, Y. Inoue, R. Tomonaga, S. Kinjo, T. Watanabe, G. Jin, W. Nagaoka, K.
Analysis of infant microbiota composition and the relationship with breast milk components in the Asian elephant (Elephas maximus) at the Zoo. Journal of Veterinary Medical Science, 2020. 82(7): 983–989.
34)    Kobayashi, R. Nagaoka, K. Nishimura, N. Koike, S. Takahashi, E. Niimi, K. Murase, H. Kinjo, T. Tsukahara, T. Inoue, R.
Comparison of the Fecal Microbiota of Two Monogastric Herbivorous and Five Omnivorous Mammals. Animal Science Journal, 2020. 91(1):e13366.
Corresponding author
35)    Takahashi, M. Takahashi, K. Abe, S. Yamada, K. Suzuki, M. Masahisa, M. Endo, M. Abe, K. Inoue, R. Hoshi, H.
Improvement of Psoriasis by Alteration of the Gut Environment by Oral Administration of Fucoidan from Cladosiphon Okamuranus. Marine Drugs, 2020, 10;18(3):154..
36)    Kimura, R. Tomiwa, K. Inoue, R. Nakata, M. Awaya, T. Kato, T. Okazaki, S. Heike, T. Hagiwara, M.
Dysregulation of oxytocin receptor (OXTR) gene in Williams syndrome. Pysconeuroendocrinology, 2020. 115:104631. doi:10.1016/j.psyneuen.2020.104631.
37)    Kambe, J. Watcharin, S. Makioka-Itaya, Y. Inoue, R. Watanabe, G. Yamaguchi, H. Nagaoka, K. 
Heat-killed Enterococcus fecalis (EC-12) supplement alters the expression of neurotransmitter receptor genes in the prefrontal cortex and alleviates anxiety-like behavior in mice. Neuroscience letters. 2020. 720. 134753
38)    Fukui, A. Takagi, T. Naito, Y. Inoue, R. Kashiwagi, S. Mizushima, K. Inada, Y. Inoue, K. Harusato, A. Dohi, O. Okayama, T. Katada, K. Kamada, K. Uchiyama, K. Ishikawa, T. Handa, O. Itoh, Y. Nakagawa, M.
Higher Levels of Streptococcus in Upper Gastrointestinal Mucosa Associated with Symptoms in Patients with Functional Dyspepsia. Digestion. 2020, 101(1): 38-45.
39)    Matsuura, J. Inoue, R. Takagi, T. Wada, S. Watanabe, A. Koizumi, T. Mukai, M. Mizuta, I. Naito, Y. Mizuno, T.
Analysis of gut microbiota in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Journal of Clinical Biochemistry and Nutrition, 2020, 65(3): 240-244.
40)    Naito, Y. Takagi, T. Inoue, R. Kashiwagi, S. Mazushima, K. Tsuchiya, S. Itoh, Y. Okuda, K. Tsujimoto, Y. Adachi, A. Maruyama, N. Oda, Y. Matoba, S.
Gut microbiota differences in elderly subjects between rural city Kyotango and urban city Kyoto: an age-gender-matched study.
Journal of Clinical Biochemistry and Nutrition, 2020, 65(2): 125-131.
41)    Andoh, A. Inoue, R. Kawada, Y. Morishima, S. Inatomi, O. Ohno, M. Bamba, S. Nishida, A. Kawahara, M. Naito, Y.
Elemental diet induces alterations of the gut microbial community in mice.
Journal of Clinical Biochemistry and Nutrition, 2020, 65(2): 118-124.
42)    Sovijit, NW. Sovijit, EW. Pu, S. Usuda, K. Inoue, R. Watanabe, G. Yamaguchi, H. Nagaoka, K.
Ovarian progesterone suppresses depression and anxiety-like behaviors by increasing the Lactobacillus population of gut microbiota in ovariectomized mice.
Neuroscience Research, 2019, S0168-0102(19)30142-7..
43)    Yasukawa, Z. Inoue, R. Ozeki, M. Okubo, T. Takagi, T. Honda, A. Naito, Y.
Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial.
Nutrients, 2019, 10;11(9), E2170
44)    Tamaki, R. Takahashi, M. Tai, S. Makioka-Itaya, M. Ijichi, T. Inoue, R. Exploratory investigation of the anti-inflammatory effects of RNase A-treated Enterococcus faecalis strain EC-12.
Bioscience Biotechnology and Biochemistry, 2019, 83(7): 1-11.
Corresponding author
45)    Tanaka, K. Nakamura, Y. Terahara, M. Yanagi, T. Nakahara, S. Furukawa, O. Tsutsui, H. Inoue, R. Tsukahara, T. Koshida, S. Poor Bifidobacterial Colonization Is Associated with Late Provision of Colostrum and Improved with Probiotic Supplementation in Low Birth Weight Infants.
Nutrients, 13;11(4). pii: E839., 2019
46)    Ushiroda, C. Naito, Y. Takagi, T. Uchiyama, K. Mizushima, K. Higashimura, Y. Yasukawa, Z. Okubo, T. Inoue, R. Honda, A. Matsuzaki, Y. Itoh, Y. Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice.
Journal of Clinical Biochemistry and Nutrition, 2019, 65(1): 35-46.
47)    Inoue, R. Sakaue, Y. Kawada, Y. Tamaki, R. Yasukawa, Z. Ozeki, M. Ueba, S. Sawai, C. Nonomura, K. Tsukahara, T. Naito, Y. Dietary supplementation with partially hydrolyzed guar gum helps improve constipation and gut dysbiosis symptoms and behavioral irritability in children with autism spectrum disorder. Corresponding author
Journal of Clinical Biochemistry and Nutrition, 2019, 64(3): 217-223
48)    Kashiwagi, S. Naito, Y. Inoue, R. Takagi, T. Nakano, T. Inada, Y. Fukui, A. Katada, K. Uchiyama, K. Itoh, Y. Mucosa-associated microbiota throughout the gastrointestinal tract from oral to rectal sites in healthy Japanese subjects. Digestion, 2019, 5:1-14.
49)    Imai, T. Inoue, R. Kawada, Y. Morita, Y. Inatomi, O. Nishida, A. Bamba, S. Kawahara, M. Andoh, A. Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease. Journal of Gastroenterology, 2019, 54(2):149-159.
50)    Shigeno, Y. Zhang, H. Banno, T. Usuda, K. Nochi, T. Inoue, R. Watanabe, G. Jin, W. Benno, Y. Nagaoka, K. Gut microbiota development in mice is affected by hydrogen peroxide generated from amino acid metabolism during lactation. FASEB Journal, 2019, 33(3):3343-3352.
51)    Kawada, Y. Naito, Y. Andoh, A. Ozeki, M. Inoue, R. Effect of storage and DNA extraction method on 16S rRNA-profiled fecal microbiota in Japanese adults. Journal of Clinical Biochemistry and Nutrition, 2019, 64(2), 106-111. Corresponding author
52)    Nakatani,M. Inoue, R. Tomonaga, S. Fukuta, K. Tsukahara, T. Production, Absorption, and Blood Flow Dynamics of Short-Chain Fatty Acids Produced by Fermentation in Piglet Hindgut during the Suckling-Weaning Period. Nutrients, 2018, 10(9), 1220
53)    Sakai, R. Watanabe, M. Akira, M. Lo, P. Wang, HT. Matsuura, R. Kodama, T. Eguchi, H. Ueno, T. Inoue, R. Nagashima, H. Okuyama, H. Miyagawa, S. The immunological response of pigs against human cell, included issues such as the production of natural antibodies in newborn. Transplantation Proceedings, 2018, 50(9), 2839-2841.
54)    Takagi, T. Naito, Y. Inoue, R. Kashiwagi, S. Uchiyama, K. Mizushima, K. Tsuchiya, S. Dohi, O. Yoshida, N. Kamada, K. Ishikawa, T. Handa, O. Konishi, H. Okuda, K. Tsujimoto, Y. Ohnogi, H. Itoh, Y. Difference in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects. Journal of Gastroenterology, 2019, 54(1):53-63.
55)    Tsukahara,T. Inatomi,T. Otomaru,K. Amatatsu,M. Romero-Perez,GA. Inoue,R. Probiotic supplementation improves reproductive performance of unvaccinated farmed sows infected with porcine epidemic diarrhea virus. Animal Science Journal, 2018, 89(8): 1144-1151.
56)    Higashimura,Y. Baba,Y. Inoue,R. Takagi,T. Uchiyama,K. Mizushima,K. Hirai,Y. Ushiroda,C. Tanaka,Y. Naito,Y. Effects of molecular hydrogen saturated alkaline electrolyzed water on intestinal environment in mice. Medical Gas Research. 2018, 8(1): 6–11.
57)    Makioka, Y. Tsukahara, T. Ijichi, T. Inoue, R.
Oral supplementation of Bifidobacterium longum strain BR-108 alters cecal microbiota by stimulating gut immune system in mice irrespectively of viability.
Bioscience Biotechnology and Biochemistry, 2018, 82(7):1180-1187. Corresponding author
58)    Nishimura, N. Tanabe, H. Komori, E. Sasaki, Y. Inoue, R. Yamamoto, T.
Transplantation of High Hydrogen-Producing Microbiota Leads to 
Generation of Large Amounts of Colonic Hydrogen in Recipient Rats Fed High 
Amylose Maize Starch. Nutrients, 2018, 29;10(2). pii: E144. doi:10.3390/nu10020144. 
59)    Hayashi, Y. Okutani, M. Ogawa, S. Tsukahara, T. Inoue, R.
Generation of anti-porcine CD69 monoclonal antibodies and their usefulness to evaluate early activation of cellular immunity by flow cytometric analysis. Animal Science Journal, 2018, 89(5):825-832. Corresponding author
60)    Okutani, M. Tsukaharam T. Kato, Y. Fukuta, K. Inoue, R. 
Gene expression profiles of CD4/CD8 double-positive T cells in porcine peripheral blood. Animal Science Journal, 2018, 89(7):979-987. Corresponding author
61)    Inoue, R. Fujiwara, S. Tsukahara, T. 
Ileal mucosal response to the same probiotic Lactobacillus strains is markedly different between suckling and adult mice. Bioscience Biotechnology and Biochemistry, 2018, 82(2):329-333. Corresponding author
62)    Tsukahara, T. Inatomi, T. Amatatsu, M. Romero-Pérez, GA. Inoue, R. 
Dietary probiotic compound improves reproductive performance of porcine epidemic diarrhea virus-infected sows reared in a Japanese commercial swine farm under vaccine control condition. Frontiers in Immunology, 2017, doi: 10.3389/fimmu.2017.01877
63)    Tsukahara,T. Inoue,R. Nakayama,K. Inatomi,T. 
Inclusion of Bacillus amyloliquefaciens strain TOA5001 in the diet of broilers suppresses the symptoms of coccidiosis by modulating intestinal microbiota. Animal Science Journal, 2018, 89(4):679-687.
64)    Takagi,T. Inoue,R. Kashiwagi, S. Uchiyama, K. Okayama, T. Dohi, W. Kamada, K. Ishikawa, T. Handa, O. Konishi, H. Itoh, Y. Tsujimoto, Y. Onogi, H. Naito, Y. 
The influence of long-term use of proton pump inhibitors on the gut microbiota: an age-sex-matched case-control study. Journal of Clinical Biochemistry and Nutrition, 2018, 62(1):100-105.
65)    Inoue,R. Sawai, T. Sawai, C. Nakatani, M. Romero-Pérez, GA. Ozeki, M. Nonomura, K. Tsukahara, T. 
A preliminary study of gut dysbiosis in children with food allergy. Bioscience Biotechnology and Biochemistry, 2017, 81(12):2396-2399. doi: 10.1080/09168451.2017.1383849. Corresponding author
66)    Patterson, A. Mulder, I. Travis, A. Lan, A. Gaboriau-routhiau, V. Cerf-bensussan, N. Garden, K. Logan, E. Delday, M. Coutts, A. Monnais, E. Ferraria, V. Inoue, R. Grant, G. Aminov, R. 
Human gut symbiont Roseburia hominis promotes and regulates innate immunity. Frontiers in Immunology, 2017, DOI: 10.3389/fimmu.2017.01166. 
67)    Nishino, K. Nishida, A. Inoue, R. Kawada, Y. Ohno, M. Sakai, S. Inatomi, O. Bamba, S. Sugimono, M. Kawahara, M. Naito, Y. Andoh, A. 
Analysis of Endoscopic Brush Samples Identified Mucosa-Associated Dysbiosis in Inflammatory Bowel Disease. Journal of Gastroenterology, 2017, doi: 10.1007/s00535-017-1384-4.
68)    Inoue,R. Ohue-Kitano R. Tsukahara, T. Tanaka, M. Masuda, S. Inoue, T. Yamakage, H. Kusakabe, T. Hasegawa, K. Shimatsu, A. Satoh-Asahara, N. Prediction of functional profiles of gut microbiota from 16S rRNA metagenomics data provides a more robust evaluation of gut dysbiosis occurring in Japanese type 2 diabetic patients. Journal of Clinical Biochemistry and Nutrition, 2017, 61(3):217-221.
69)    Higashimura, Y. Baba, Y. Inoue, R. Takagi, T. Mizushima, K. Ohnogi, H. Honda, A. Matsuzaki, Y. Niato, Y. 
Agaro-oligosaccharides Regulates Gut Microbiota and Adipose Tissue Accumulation in Mice. Journal of Nutritional Science and Vitaminology, 2017, 63(4):269-276.
70)    Inoue, R. Yajima, T. Tsukahara, T. 
Expression of TLR2 and TLR4 in murine small intestine during postnatal development. Bioscience Biotechnology and Biochemistry, 2017, 81(2):350-358 Corresponding author
71)    Otuska, T. Sugimoto, M, Inoue, R. Ohno, M. Ban, H, Nishida, A. Inatomi, O. Takahashi, S. Naito, Y. Andoh, A. 
Influence of potassium-competitive acid blocker on the gut microbiome of Helicobacter pylori-negative healthy individuals. Gut, 2016, DOI:10.1136/gutjnl-2016-313312
72)    Inoue, R. Sakaue, Y. Sawai, C. Sawai, T. Ozeki, M. Romero-Pérez, GA, Tsukahara, T.
A preliminary investigation on the relationship between gut microbiota and gene expressions in peripheral mononuclear cells of infants with Autism Spectrum Disorders. Bioscience Biotechnology and Biochemistry, 2016, 80(12), 2450-2458. Corresponding author
73)    Romero-Pérez, GA, Egashira, M. Tsuruta, T. Oda, Y. Ueda, F. Tsukahara, T. Tsukamoto, T. Inoue, R.
Orally administered Salacia reticulata extract reduces H1N1 influenza clinical symptoms in murine lung tissues putatively due to enhanced natural killer cell activity.
Frontiers in Immunology, 2016, 31;7:115. doi: 10.3389/fimmu.2016.00115.
Corresponding author
74)    Ogawa, S. Tsukahara, T. Imaoka, T. Nakanishi, N. Ushida, K. and Inoue, R.
The effect of colostrum ingestion during the first 24 h of life on early postnatal development of piglet immune systems.
Animal Science Journal, 2016, 10.1111/asj.12573. Corresponding author
75)    Ogawa, S. Okutani, M. Tsukahara, T. Nakanishi, N. Kato, Y. Fukuta, K. Romero-Pérez, GA. Ushida, K. and Inoue, R.
Comparison of gene expression profiles of T cells in porcine colostrum and peripheral blood. 
American Journal of Veterinary Research, 2015, 77(9), 961-968. Corresponding author
76)    Inoue, R. Tsukahara, T. Nakatani, M. Okutani, M. Nishibayashi, R. Ogawa, S. Harayama, T. Nagino, T. Hatanaka, H. Fukuta, K. Romero-Pérez, GA. Ushida, K. and Kelly, D.
Weaning Markedly Affects Transcriptome Profiles and Peyer’s Patch Development in Piglet Ileum. 
Frontiers in Immunology, 2015, 6:630. doi: 10.3389/fimmu.2015.00630 Corresponding author
77)    Nishibayashi, R. Inoue, R. Harada, Y. Watanabe, T. Makioka, Y. Ushida, K.
RNA of Enterococcus faecalis strain EC-12 is a major component inducing interleukin-12 production from human monocytic cells.
PLOS ONE, 2015, DOI: 10.1371/journal.pone.0129806 Corresponding author
78)    Tsukahara, T. Inoue, R. Nakatani, M. Fukuta, K. Kishino, E. Ito, T. Ushida, K.
Influence of weaning age on the villous height and disaccharidase activities in the porcine small intestine.
Animal Science Journal, 2015 doi: 10.1111/asj.12399
79)    Ogawa, S. Tsukahara, T. Tsuruta, T. Nishibayashi, N. Okutani, M. Nakatani, M. Higashide, K. Iida, S. Nakanishi, N. Ushida, K. Inoue, R.
The evaluation of secretion volume and immunoglobulin A and G concentrations in sow colostrum from anterior to posterior teats.
Animal Science Journal, 2014, 85(6), 678-682. Corresponding author
80)    Tsukahara, T. Matsukawa, N. Tomonaga, S. Inoue, R. Ushida, K. Ochiai, K.
High-sensitivity detection of short-chain fatty acids in porcine ileal, cecal, portal and abdominal blood by gas chromatography-mass spectrometry.
Animal Science Journal, 2014, 85(4), 494-498.
81)    Matsumoto, M. Hagio, M, Inoue, R. Mitani, T. Yajima, M, Hara, H. Yajima, T.
Long-term oral feeding of lutein-fortified milk increases voluntary running distance in rats.
PLOS ONE, 2014, DOI: 10.1371/journal.pone.0093529
82)    Ogawa, S. Tsukahara, T. Nishibayashi,R. Nakatani, M. Okutani, M. Nakanishi, N. Ushida, K. Inoue, R.
Shotgun proteomic analysis of porcine colostrum and mature milk.
Animal Science Journal, 2014, 85(4), 440-448. Corresponding author
83)    Tsuruta, T. Inoue, R. Nagino, T. Nishibayashi, R. Makioka, Y. Ushida,K.
Role of the mannose receptor in phagosytosis of Enterococcus faecalis strain EC-12 by antigen-presenting cells.
MicrobiologyOpen, 2013, 2(4), 610-7
84)    Tsuruta, T. Inoue, R. Tsushima, T. Watanabe, T. Tsukahara, T. Ushida,K.
Oral administration of EC-12 increases the baseline gene expression of anti-viral cytokine genes, IFN-γ and TNF-α, in splenocytes and mesenteric lymph node cells of weaning piglets.
Bioscience of Microbiota, Food and Health, 2013, 32(4):123-8.
85)    Inoue,R. Tsukahara,T. Matsukawa, M. Watanabe, T. Bukawa, W. Nakayama, K. Ushida, K.
Rapid induction of an immune response in rat peyer’s patch after oral administration of Enterococcus faecalis strain EC-12.
Bioscience Biotechnology and Biochemistry, 2013, 77(4), 863-866.
86)    Gustavo, AP. Inoue, R. Ushida,K. Yajima,T.
A rapid method of screening lactic acid bacterial strains for conjugated linoleic acid production.
Bioscience Biotechnology and Biochemistry, 2013, 77(3), 648-650.
87)    Ishizuka, A. Tomizuka, K. Aoki, R. Nishijima, T. Saito, Y. Inoue, R. Ushida, K. Mawatari, T. Ikeda, T.
Effects of administration of Bifidobacterium animalis subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans.
Journal of Bioscience and Bioengineering, 2012, 113(5), 587-591
88)    Tsukahara, T. Kishino, E. Inoue, R. Nakanishi, N. Nakayama, K. Itoh, T. and Ushida, K.
Correlation between villous height and the disaccharidase activity in the small intestine of piglets from nursing to growing.
Animal Science Journal, 2012, DOI: 10.1111/j.1740-0929.2012.01039.x
89)    Tsuruta, T. Inoue, R. Tsukahara, T. Nakamoto, M. Hara, H. Ushida, K. and Yajima, T.
Commensal bacteria coated by secretory immunoglobulin A and immunoglobulin G in the gastrointestinal tract of pigs and calves.
Animal Science Journal, 2012, 83(12), 799-804. Corresponding author
90)    Tsukahara, T. Yoshida, Y. Tsushima, T. Watanabe, T. Matsubara, N, Inoue, R. and Ushida, K.
Evaluation of heat-killed and dried cell preparation of Enterococcus faecalis against villous atrophy in early-weaned mice and pigs.
Animal Science Journal, 2011, 82(2), 302-306.
91)    Yajima, T. Inoue, R. Yajima, M. Tsuruta, T. Karaki, S. Hira, T. and Kuwahara, A.
The G-protein on cholesterol-rich membrane microdomains mediates mucosal sensing of short-chain fatty acid and secretory response in rat colon.
Acta Physiol, 2011, 203(3), 381-9
92)    Yoshikawa, T. Inoue, R. Matsumoto, M. Yajima, T. Ushida, K and Iwanaga, T.
Comparative expression of hexose transporters (SGLT1, GLUT1, GLUT2 and GLUT5) throughout the mouse gastrointestinal tract.
Histochemistry and Cell Biology, 2011, 135(2), 183-194. Corresponding author
93)    Inoue, R. Nagino, T. Hoshino, G. and Ushida, K.
Nucleic acids of Enterococcus faecalis strain EC-12 are potent Toll-like receptor 7 and 9 ligands inducing interleukin-12 production from murine splenocytes and murine macrophage cell line J774.1.
FEMS Immunology & Medical Microbiology, 2011, 61(1), 94-102.
94)    Yajima, T. Inoue, R. Matsumoto, M. and Yajima, M.
Non-neuronal release of ACh plays a key role in secretory response to luminal propionate in rat colon.
Journal of Physiology, 2011, 589(4), 953-962.
95)    Ushida, K. Hatanaka, H. Inoue, R. Tsukahara, T. and Phillips GO.
Effect of long term ingestion of gum Arabic on the adipose tissues of female mice.
Food hydrocolloids, 2010, 25(5), 1344-1349.
96)    Teramae, H. Yoshikawa, T. Inoue, R. Ushida, K. Takebe, K. Nio-Kobayashi, J. and Iwanaga, T.
The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract.
Biomedical Research, 2010, 31(4), 239-249.
97)    Inoue,R. Tsukahara, T. Ueno, K. Kitabayashi, T. and Ushida, K.
Possible Link of a Compositional Change in Intestinal Micriobiota with the Anti-allergic Effect of Fructo-oligosaccharides in NC/jic Mice.
Bioscience Biotechnology and Biochemistry, 2010, 74(9), 1947-1950.
98)    Ushida, K. Yoshida, Y. Tsukahara, T., Watanabe, T. and Inoue, R.
Oral administration of Enterococcus faecalis EC-12 cell preparation improves villous atrophy after weaning through enhancement of growth factor expression in mice.
Biomedical Research, 2010, 31(3), 191-198.
99)    Tsuruta, T. Inoue, R. Iwanaga,T. Hara, H. and Yajima, T.
Development of a method for the identification of S-IgA-coated bacterial composition in mouse and human feces.
Bioscience Biotechnology and Biochemistry, 2010, 74(5), 968-973. Corresponding author
100)    Tsukahara, T. Inoue, R. Shimojo, N. Nakayama, K. Saito, S. Sato, T. Itoh, T. Fujita and K. Ushida, K.
α-Linked Galactooligosaccharide Suppresses Small Intestinal Eosinophil Infiltration and Improves Growth Performance in Weaning Pigs. 
The Journal of Veterinary Medical Science, 2010, 72(5), 547-553.
101)    Tsukahara, T. Inoue, R. Yamada, K. and Yajima,T.
A mouse model study for the villous atrophy of the early weaning piglets.
The Journal of Veterinary Medical Science, 2009,72(2), 241-244.
102)    Matsukawa, N. Matsumoto, M. Shionoki, A. Hagio, M. Inoue, R. and Hara, H.
Nondigestible saccarides suppress the bacterial degradation of quercetin aglycone in the large intestine and enhance the bioavailability of quercetin glucoside in rats.
Journal of Agricultural and Food Chemistry, 2009, 57(20), 9462-9468.
103)    Tsuruta,T. Inoue,R. Nojima,I. Tsukahara,T. Hara,H. and Yajima,T.
The amount of secreted IgA may not determine the secretory IgA coating ratio of gastrointestinal bacteria.
FEMS Immunology & Medical Microbiology, 2009, 56(2), 185-189. Corresponding author
104)    Yoshikawa,T. Inoue,R. Yoshida,Y. Watanabe,T. Bukawa,W. and Ushida,K.
Diverse Immune Responses to Orally Administrated Heat-Killed Cell Preparation of Enterococcus faecalis Strain EC-12 in Immune Tissues in Mice.
Bioscience Biotechnology and Biochemistry, 2009, 73(6), 1439-42.
105)    Matsumoto,M. Inoue,R. Tsuruta, T. Hara, H and Yajima,T.
Long-term oral administration of cow's milk improves insulin sensitivity in rats fed a high-sucrose diet.
British Journal of Nutrition, 2009, doi:10.1017/S0007114509990365.
106)    Tsuruta,T. Inoue,R. Tsukahara,T Matsubara,N. Hamasaki,M and Ushida,K. 
A cell preparation of Enterococcus faecalis strain EC-12 stimulates the luminal immunoglobulin-A secretion in juvenile calves.
Animal Science Journal, 2009, 80(2), 206-211.
107)    Inoue, R. Tsuruta, T. Nojima, I. Nakayama, K. Tsukahara, T. Yajima, T.
Postnatal changes in the expression of genes for cryptdins 1– 6 and the role of luminal bacteria in cryptdin gene expression in mouse small intestine.
FEMS Immunology & Medical Microbiology, 2008, 52(3), 407-416. Corresponding author
108)    Matsumoto, M. Inoue, R. Tsukahara, T. Ushida, K. Chiji, H. Matsubara, N. Hara, H.
Voluntary Running Exercise Alters Micribiota Composition and Increases n-Butyrate Concentration in the Rat Cecum.
Bioscience Biotechnology and Biochemistry, 2008,72(2), 572-576.
109)    Inoue, R. Otsuka, M. Nishio, A. Ushida, K.
Primary administration of Lactobacillus johnsonii NCC533 in weaning period suppresses the elevation of pro-inflammatory cytokines and CD86 gene expressions in skin lesions in NC/Nga mice.
FEMS Immunology & Medical Microbiology 2007, 50(1): 67-76.
110)    Inoue, R. Tsukahara, T. Noda, M. Bukawa, W. Matsubara, N. Ushida, K.
Oral Administration of a Heat-killed Cell Preparation of Enterococcus faecalis Strain EC-12 Stimulates the Gene Expression of Na+-K+-2Cl- Co-Transporter 1 in Rat Ileal Epithelial Cells.
Bioscience Biotechnology and Biochemistry 2007, 71(3): 807-810.
111)    Inoue, R. Nishio, A. Fukushima ,Y. and Ushida, K.
Oral treatment with probiotic Lactobacillus johnsonii NCC533 (La1) for a specific part of the weaning period prevents the development of atopic dermatitis induced after maturation in model mice, NC/Nga. 
British Journal of Dermatology 2007, 156(3): 499-509. 
112)    Tsukahara, T., Inoue,R., Nakanishi, N., Nakayama, K., Matsubara, N., Ushida, K. Evaluation of the low dose level of a heat-killed and dried cell preparation of Enterococcus faecalis to prevent porcine edema disease using experimental infection model with enterotoxcemic Escherichia coli in weaning pigs.
The Journal of Veterinary Medical Science 2006, 69(2): 103-109.
113)    Inoue, R. Tsukahara, T. Sunaba, C. Itoh, M. and Ushida, K. 
Simple and rapid detection of the porcine reproductive and respiratory syndrome virus from pig whole blood using filter paper. 
Journal of Viirological Methods 2006, 141(1): 102-106.
114)    Inoue, R. Otsuka, M. and Ushida, K.
Development of intestinal microbiota in mice and its possible interaction with the evolution of luminal IgA in the intestine.
Experimental Animals 2005, 54(5):437-445. 
115)    Inoue, R. Tsukahara, T. Nakanishi, N. and Ushida, K.
Development of the intestinal microbiota in the piglet.
The Journal of General and Applied Microbiology 2005, 51(4): 257-265. 
116)    Inoue, R. and Ushida, K.
Vertical and horizontal transmissions of the intestinal commensal bacteria in the rat model.
FEMS Microbiology Ecology 2003, 46(2): 213-219. 
117)    Inoue, R. and Ushida, K.
Development of the intestinal microbiota in rats and its possible interactions with the evolution of the luminal IgA in the intestine.
FEMS Microbiology Ecology 2003, 45(2): 147-153. 
118)    Ohashi, Y. Inoue, R. Tanaka, K. Umesaki,Y. and Ushida, K.
Strain Gauge Force Transducer and Its Application in a Pig Model to Evaluate the Effect of Probiotic on Colonic Motility. 
Journal of Nutritional Science and Vitaminology 2001, 47(5): 351-356.
119)    Ohashi, Y. Inoue, R. Tanaka, K. Matsuki, T. Umesaki, Y. and Ushida, K.
Lactobacillus casei strain Shirota-fermented milk stimulates indigenous Lactobacilli in the pig intestine. 
Journal of Nutritional Science and Vitaminology 2001, 47(2): 172-176.



  1. Inoue, R. Tsukahara, T. Composition and physiological functions of the porcine colostrum. Animal science journal, 2021, 92(1), e13618. https://doi.org/10.1111/asj.13618

  2. Naito, Y. Takagi, T. Inoue, R. Role of Gut Microbiota in Bile-Acid Metabolism. In: Takada, A. , Himmerich, H. , editors. Psychology and Pathophysiological Outcomes of Eating [Internet]. London: IntechOpen; 2021

  3. Nishida, A. Inoue, R. Inatomi, O. Bamba, S. Naito, Y. Andoh, A. Gut microbiota in the pathogenesis of inflammatory bowel disease. Clinical Journal of Gastroenterology, 2017 https://doi.org/10.1007/s12328-017-0813-5.

  4. Naito, Y. Kashiwagi, K. Takagi, T. Andoh, A. Inoue, R. Intestinal dysbiosis secondary to proton-pump inhibitor use. Digestion, 2018;97(2):195-204. 

  5. Arleevskaya, M. Manukyan, G. Inoue, R. Aminov, R. Environmental factors in autoimmune and inflammatory disease. Frontiers in Immunology. 2017, doi: 10.3389/fimmu.2017.00243 (E-Book)

  6. Inoue, R. and Tsukahara, T. Development of the porcine intestine during early postnatal life -Evaluation focusing on histological, enzymatic and immunological parameters-. Japan Society of Animal Nutrition and Metabolism, 2016, 60(2), 99-109. 

  7. 井上亮・阪上由子・塚原隆充 第II編第7章 自閉症スペクトラム障害 (落合邦康 監修) 「腸内細菌・口腔細菌と全身疾患 」 CMC出版 2015年, pp73-82.

  8. 井上亮 腸管免疫系の発達 「消化管の栄養・生理と腸内細菌」 アニマルメディア社出版 2011年, pp205-213. 

  9. 牛田一成・亀上知世子・井上亮・塚原隆充・大橋雄二

  10. 腸内環境と腸管組織の生理応答 「腸内フローラの共生・認識」(光岡知足 編)学会出版センター 2006, pp.41-50.